diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis

The diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis.

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. The aim of this study was to evaluate the diagnostic value of anti CCP antibodies in patients with RA. This study included three groups; group I: 60 early diagnosed RA patients selected according to the ACR, group II: 30 patients of arthritis other than RA, group III: 10 healthy age and sex matche...

Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis

BACKGROUND Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been of diagnostic value in Northern European Caucasian patients with rheumatoid arthritis (RA). In these populations, anti-CCP antibodies are associated with the HLA-DRB1 shared epitope. We assessed the diagnostic value of anti-CCP antibodies in Greek patients with RA where the HLA shared epitope was reported in a minority...

[Diagnostic and prognostic value of antibodies to cyclic citrullinated peptide (Anti-CCP) in rheumatoid arthritis].

There is strong evidence that the determination of autoantibodies against filaggrine is a very useful tool for the diagnosis of rheumatoid arthritis (RA). Anti-cyclic citrullinated peptide antibodies (Anti-CCP)-ELISA appear to be the most efficient test among those available for the detection of antifilaggrine autoantibodies, as it has the best diagnostic accuracy for the diagnosis of RA. Furth...

Citrulline and anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis

Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis.

OBJECTIVE To assess the additional diagnostic and clinical value of the second test generation of anti-cyclic citrullinated peptide antibodies (CCP2) compared with rheumatoid factor isotypes (IgG-RF, IgA-RF, IgM-RF) in patients with rheumatoid arthritis. METHODS This was a prospective study on 715 patients: rheumatoid arthritis (n = 295), degenerative or other inflammatory joint disease (n = ...

Diagnostic value of third generation anti-cyclic citrullinated peptide assay in rheumatoid factor negative rheumatoid arthritis

Objective: This study aimed to evaluate the diagnostic usefulness of second and third generation anticyclic citrullinated peptide (anti-CCP2 and anti-CCP3) assays in Chinese patients with rheumatoid arthritis (RA), and to identify the potential advantages of anti-CCP3 diagnosis in rheumatoid factor (RF) negative RA patients. Methods: Serum samples were obtained from 148 RA patients and 120 cont...